People with the last name O'Brian in North Carolina
- Alley O'Brian
- Amy O'Brian
- Andrea O'Brian
- Beverly O'Brian
- Bob O'Brian
- Charlotte O'Brian
- Conan O'Brian
- Cyndi O'Brian
- Cynthia O'Brian
- David O'Brian
- Estelle O'Brian
- James O'Brian
- Jenny O'Brian
- Joe O'Brian
- Kevin O'Brian
- L O'Brian
- Laurence O'Brian
- Lockett O'Brian
- Mackie O'Brian
- Madison O'Brian
- Martin O'Brian
- Matt O'Brian
- Mike O'Brian
- Robert O'Brian
- Sam O'Brian
- Samuel O'Brian
- Speed O'Brian
- Tina O'Brian
- Wally O'Brian
- Yolanda O'Brian
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