People with the last name O'Donoghue in South Carolina
- Akiko O'Donoghue
- Amy O'Donoghue
- Ann O'Donoghue
- Austin O'Donoghue
- Brian O'Donoghue
- Bridget O'Donoghue
- Brittany O'Donoghue
- Clement O'Donoghue
- Conner O'Donoghue
- David O'Donoghue
- Deborah O'Donoghue
- Edward O'Donoghue
- Eric O'Donoghue
- Francis O'Donoghue
- H O'Donoghue
- Helen O'Donoghue
- James O'Donoghue
- John O'Donoghue
- Leo O'Donoghue
- Louise O'Donoghue
- Margaret O'Donoghue
- Martin O'Donoghue
- Mary O'Donoghue
- Morgan O'Donoghue
- Nancy O'Donoghue
- Paul O'Donoghue
- Peg O'Donoghue
- Rm O'Donoghue
- Roderick O'Donoghue
- Rosemarie O'Donoghue
- Sean O'Donoghue
- Sharon O'Donoghue
- Stephen O'Donoghue
- Yonni O'Donoghue
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